Research reportEffect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats
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Effects of neonatal dopaminergic lesion on oral cocaine self-administration in rats: Higher female vulnerability to cocaine consumption
2022, Pharmacology Biochemistry and BehaviorCitation Excerpt :The dopaminergic ventral tegmental area (VTA) projections to the prefrontal cortex (PFC) and to the nucleus accumbens are central in reward and motivation (Klein et al., 2019; Wise, 2009). The neonatal dopamine lesion using 6-hydroxydopamine (6-OHDA), traditionally used as an animal model of attention-deficit/hyperactivity disorder because of its ability to cause hyperactivity in male rats (Kostrzewa et al., 2015), has been applied to better understand the role of the dopaminergic system in drug self-administration and how the behavioral effects of this lesion may modulate drug intake in rats (Caine and Koob, 1994; Gerrits and Van Ree, 1996). A dopaminergic lesion performed in adulthood demonstrates behavioral changes in cocaine self-administration with a significant reduction in drug seeking behavior (Roberts et al., 1977; Sizemore et al., 2004).
Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats
2020, NeuroscienceCitation Excerpt :Nicotine, via nAChRs in the VTA and Acb, activates mesolimbic reward pathway and releases dopamine in the Acb which results in reward behavior (Dani and Heinemann, 1996; Mansvelder and McGehee, 2000; Laviolette and Van der Kooy, 2004). Lesions in the mesolimbic pathway disrupt the self-administration of drugs of abuse (Corrigall et al., 1992; Rassnick et al., 1993; Gerrits and Van Ree, 1996). nAChRs are expressed by excitatory and inhibitory neurons that control excitability of dopamine neurons (Mansvelder et al., 2007).
Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil
2020, Brain ResearchCitation Excerpt :These authors also reported a significant reduction in accumbal dopamine transporter (DAT) phosphorylation at 24 h post-RTI administration. It is unclear whether such changes could underlie the effects observed here, especially given that accumbal dopamine signaling may be less critical for opioid reward behavior compared to psychostimulants (Gerrits et al., 1994; Gerrits and Van Ree, 1996; Pettit et al., 1984), although see (Corre et al., 2018). Thus, it will be critical for future studies to examine how orexin peptides acting at Ox1R are important for the normal functioning of opioid reward pathways.
Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons
2017, Neuroscience and Biobehavioral ReviewsEmerging targets for addiction neuropharmacology: From mechanisms to therapeutics
2016, Progress in Brain ResearchCitation Excerpt :Of note, CPP is highly influenced by mesolimbic DA transmission DA, whereas heroin-self-administration is largely independent from DA. This could explain why NOP agonists, even though able to blunt NAc DA levels and morphine CPP, do not affect operant responding for heroin (Gerrits and Van Ree, 1996; Sanchis-Segura and Spanagel, 2006; Tzschentke, 2007). NOP activation was shown to be effective also in preventing cocaine- and amphetamine-induced CPP (Kotlinska et al., 2002; Zhao et al., 2003); moreover, mice with constitutive deletion of NOP receptors were more sensitive to the effects of cocaine in a CPP paradigm (Marquez et al., 2008; Sakoori and Murphy, 2008).