Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats
References (45)
- et al.
Rat brain cytochromes P-450: catalytic immunochemical properties and inducibility of multiple forms
Brain Res.
(1990) - et al.
Transgenic rats carrying the mouse renin gene: Morphological characterization of a low-renin hypertension model
Kidney Int.
(1992) - et al.
Mapping and computer assisted morphometry and microdensitometry of glucocorticoid receptor immunoreactive neurons and glial cells in the rat central nervous system
Neuroscience
(1994) - et al.
Subcellular localization of cytochrome P450 and activities of several enzymes responsible for drug metabolism in the human brain
Biochem. Pharmacol.
(1993) - et al.
Regional distribution of ethanol-inducible cytochrome P45011E1 in the rat central nervous system
Neuroscience
(1990) - et al.
Studies of the immunohistochemical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain
Biochem. Biophys. Acta
(1990) - et al.
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
Brain Res.
(1993) - et al.
P450c11B3 mRNA transcribed from a third P450c11 gene is expressed in a tissue-specific developmentally and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylsae and 18-hydroxylase activities
J. Biol. Chem.
(1995) - et al.
Localization of NADPH cytochrome P450 oxidoreductase in rat brain by immunohistochemistry and in situ hybridization and a comparison with the distribution of neuronal NADPH-diaphorase staining
Neuroscience
(1994) - et al.
Evidence that estradiol-2/4-hydroxylase activities in rat hypothalamus and hippocampus differ qualitatively and involve multiple forms of P-450: ontogenetic and inhibition studies
J. Steroid Biochem.
(1985)
Mapping of phenytoin-inducible cytochrome P450 immunoreactivity in the mouse central nervous system
Neuroscience
Identification and localization of cytochromes P450 expressed in brain
Methods Enzymol.
Regulation of cytochrome P450 in the central nervous system
J. Steroid Biochem. Mol. Biol.
Aspects of neural plasticity in the central nervous system. I. Computer-assisted image analysis methods
Neurochem. Int.
The chronic administration of nicotine induces cytochrome P450 in rat brain
J. Neurochem.
A membrane receptor mechanism for steroid hormones reinitiating meiosis inXenopus laevis oocytes
Dev. Growth Differ.
Morphological evidence for a close interaction of chromaffm cells with cortical cells within the adrenal gland
Cell Tissue Res.
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes
Histochem. Cell Biol.
Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor
Endocrinology
11β-Hydroxylase gene expression in the rat adrenal cortex
J. Endocrinol.
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction
Mol. Cell. Biochem.
Effect of dietary sodium restriction on mRNA for aldosterone synthase cytochrome P-450 in rat adrenals
J. Biochem.
Cited by (17)
Effects of the combination of metyrapone and oxazepam on cocaine-induced increases in corticosterone in the medial prefrontal cortex and nucleus accumbens
2017, PsychoneuroendocrinologyCitation Excerpt :The different effects of cocaine on corticosterone in these two brain regions could be due to the differences in expression of the enzymes involved in corticosterone synthesis in the brain. The mRNA for 11β-hydroxylase, the enzyme that converts 11-deoxycortisol to cortisol, has been shown to be expressed mainly in the cortex and brainstem (Erdmann et al., 1996; Ye et al., 2008). Thus, corticosterone may play a larger functional role in the medial prefrontal cortex in comparison to the nucleus accumbens.
Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics
2016, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The ability of particular brain regions to locally enhance (or attenuate) the presence of GCs could offer a mechanism for increasing the efficiency of central stress response, i.e. to increase the chances that specific stress-related brain areas (like PFC) will recruit the (GR-dependent) neuronal mechanisms required for a successful behavioural adaptation to stress. Data indicating high degree of cellular co-localization between GRs, 11βHSD isoform 1 and P450c11β support this notion (Roland et al., 1995; Erdmann et al., 1996). From another point of view, the ability of the brain to independently produce GC precursors mediated by a different enzyme (CYP2D6) compared to corresponding adrenal biosynthesis (P450c21) should probably be considered when trying to study the effects of GC deficiency in the brain due to P450c21 deficiency (congenital adrenal hyperplasia).
The CYP11B subfamily
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Another important aspect is the expression of the CYP11B enzymes in extra-adrenal tissues. There is evidence for an expression in rat and human brain but the physiological function remains unclear [41,42]. The CYP11B2 expression in heart is controversial [43–45].
Modulation of aldosterone and cortisol synthesis on the molecular level
2004, Molecular and Cellular EndocrinologySteroidogenic enzyme gene expression in the human brain
2002, Molecular and Cellular EndocrinologyCentral hypertensive effects of aldosterone
1997, Frontiers in Neuroendocrinology