Elsevier

Brain Research

Volume 733, Issue 2, 16 September 1996, Pages 287-291
Brain Research

Short communication
Cerebral uric acid increases following experimental traumatic brain injury in rat

https://doi.org/10.1016/0006-8993(96)00669-5Get rights and content

Abstract

Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.

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    1

    Present address: Department of Neurology - Los Angeles County & University of Southern California Medical Center, 1200 N. State Street, Unit 1, Room 5641, Los Angeles, CA 90033, USA.

    2

    Present address: Department of Microbiology and Immunology, Temple University School of Medicine, Kresge Hall, Room 503, Philadelphia, PA 19140, USA.

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