Immunoregulation mediated by the sympathetic nervous system, II
References (7)
- et al.
Cell. Immunol
(1979) - et al.
Life Sci
(1976) - et al.
Clin. Exp. Immunol
(1977)
Cited by (91)
Deletion of muscarinic type 1 acetylcholine receptors alters splenic lymphocyte functions and splenic noradrenaline concentration
2015, International ImmunopharmacologyCitation Excerpt :Sympathetic fibers can be traced into the spleen to T cell-rich periarteriolar lymphoid sheats (PALS) and around lymphocyte follicles, the locations where adaptive immune responses are shaped in this organ [6]. Experiments based on electrophysiological and pharmacological approaches have clearly shown that noradrenaline (NA), the main sympathetic neurotransmitter, can influence the activity of immune cells in the spleen [4,7–10]. On the other hand, the immune response itself can reciprocally influence sympathetic activity in the spleen [8,11,12].
Neuroendocrine regulation of inflammation
2014, Seminars in ImmunologyCitation Excerpt :These pathways include the SNS, which releases the neurotransmitter NE from nerve terminals, and/or the HPA axis, which releases a variety of hormones, such as corticosteroids. Also, they showed that the SNS regulated the magnitude of an antibody response [16,17]. Thus, an immune-to-brain, as well as a brain-to-immune, circuit was now in place to explain how immunity might affect behavior and vice versa.
Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems - 2011 Curt Richter Award Winner
2012, PsychoneuroendocrinologyCitation Excerpt :These pathways are characterized by distinct, target organ specific activity patterns, making it necessary to view SNS activity in light of the target tissue of interest (Jänig and Habler, 2003; Malpas, 2010). One of the target organs of the SNS is the innate immune system, and that adrenergic signaling can affect inflammatory pathways (Besedovsky et al., 1979; del Rey et al., 1981; Sanders and Munson, 1984). A neuroendocrine immune feedback loop was proposed similar to the loop involving the HPA axis, in which peripheral immune activation would signal to the CNS, activate the SNS, thus allowing the CNS to sense and control peripheral inflammation (e.g. Besedovsky and del Rey, 1996; Elenkov et al., 2000; Kohm and Sanders, 2000; Sternberg, 2006).
Role of the Sympathetic Nervous System in Immunity
2010, New Insights to Neuroimmune BiologyEffects of L-arginine and L-lysine mixtures on splenic sympathetic nerve activity and tumor proliferation
2009, Autonomic Neuroscience: Basic and ClinicalNeuropeptide Y (NPY) and NPY Y1 receptor in periodontal health and disease
2009, Archives of Oral BiologyCitation Excerpt :Our current studies are now focused on determining the contribution of the sympathetic nervous system to adaptive homeostatic control and ultimately its role in oral health and disease. Sympathetic nerves have conventionally been associated with inhibitory effects on immune mechanisms6 and it has been suggested that sympathetic nerves modulate both inflammation and bone remodelling in vivo.7,8 It is therefore of interest to determine the levels and potential functionality of neurotransmitters associated with sympathetic nerves in inflammatory diseases associated with unregulated bone turnover, such as periodontitis.