Suppression of splenic macrophage interleukin-1 secretion following intracerebroventricular injection of interleukin-1β: Evidence for pituitary-adrenal and sympathetic control

doi:10.1016/0008-8749(91)90008-Y

Cellular Immunology

Volume 132, Issue 1, January 1991, Pages 84-93

https://doi.org/10.1016/0008-8749(91)90008-Y Get rights and content

Abstract

Intracerebroventricular (ICV) injections of interleukin-1 beta (IL-1β) produced a dose-dependent increase in plasma corticosterone and adrenocorticotropic hormone (ACTH) within 2 hr of injection and then declined over the next 24 hr. Using a potent steroidogenic dose of IL-1β (5 ng), ICV injection resulted in suppression of splenic macrophage IL-1 secretion following stimulation by LPS in vitro. Macrophage TGF-β secretion was not affected, indicating a differential action of ICV IL-1β on macrophage cytokine production. Following adrenalectomy (ADX), the suppressive effect of ICV IL-1β was reversed and resulted in stimulation of macrophage IL-1 secretion, indicating that the suppression was mediated by adrenocorticol activation. However, surgical interruption of the splenic nerve to eliminate autonomic innervation of the spleen also prevented the macrophage suppressive signal in rats given ICV IL-1β. Furthermore, the combination of ADX and splenic nerve section resulted in a potent stimulatory effect of ICV IL-1β on splenic macrophage IL-1 secretion which was greater than either ADX or splenic nerve section alone. These results support the concept of a negative feedback on macrophage IL-1 secretion by the central action of IL-1β and indicate that both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system mediate this effect.

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^☆: This work was supported by grants from the USDHS, The RJR Nabisco Corporation, the MRC of Canada. AHG is a Terry Fox Scientist of the National Cancer Institute of Canada.

²: Current Address: Department of Psychology, University of Newcastle, Shortland, 2308 Australia.

³: Current Address: Department of Pathology, 236 Basic Medical Sciences Bldg., University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada, R3E OW3.

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Suppression of splenic macrophage interleukin-1 secretion following intracerebroventricular injection of interleukin-1β: Evidence for pituitary-adrenal and sympathetic control☆

Abstract

Physiol. Behav

Life Sci

Brain Res. Bulletin

Cell Immunol

Biochem. Biophys. Res. Commun

J. Immunol

J. Immunol

FASEB J

Ann. N.Y. Acad. Sci

Science

Science

Endocrinology