Suppression of splenic macrophage interleukin-1 secretion following intracerebroventricular injection of interleukin-1β: Evidence for pituitary-adrenal and sympathetic control☆
References (25)
Physiol. Behav
(1988)- et al.
Life Sci
(1989) - et al.
Brain Res. Bulletin
(1984) - et al.
Cell Immunol
(1979) - et al.
Biochem. Biophys. Res. Commun
(1980) - et al.
J. Immunol
(1987) - et al.
J. Immunol
(1982) FASEB J
(1988)- et al.
Ann. N.Y. Acad. Sci
(1987) - et al.
Science
(1986)
Science
Endocrinology
Cited by (96)
Neural regulation of gastrointestinal inflammation: Role of the sympathetic nervous system
2014, Autonomic Neuroscience: Basic and ClinicalAutonomic regulation of cellular immune function
2014, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :They report that electrically stimulating the cut efferent fibers of the vagus nerve inhibits endotoxin-induced sepsis, TNF-α production, and localized inflammation in a dermal air pouch, all depend on the activation of cholinergic α7 nicotinic receptors (Wang et al., 2003). No studies have been carried out by this group to rule out the possibility that their effects could be mediated by the SNS, even though Nance, Greenberg and colleagues (Brown et al., 1991; Vriend et al., 1993) and others (Yoon et al., 2006) have reported similar suppression of local and systemic inflammation and splenic macrophages TNF-α production that are sympathetically-mediated. More recently, Tracey (2009) has acknowledged the absence of efferent vagal innervation of the spleen, proposing instead that the vagal efferents innervate prevertebral sympathetic postganglionic neurons that distribute to the spleen.
Brain injury, immunity and infections
2012, Annales Francaises d'Anesthesie et de ReanimationThe role of stress mediators in modulation of cytokine production by ethanol
2009, Toxicology and Applied PharmacologyPsychoneuroimmune Implications of Type 2 Diabetes: Redux
2009, Immunology and Allergy Clinics of North AmericaCitation Excerpt :Receptors for IL-1 have been identified in the hypothalamus, and IL-1β has been shown to induce the release of adrenocorticotropic hormone (ACTH) indirectly via corticotropin releasing factor in a dose-dependent manner.131 It has been suggested that a negative feedback loop on macrophage IL-1 secretion is mediated by the HPA axis and sympathetic nervous system by the actions of central IL-1β.132 The primary route of HPA activation by the actions of peripheral IL-1β appears to be accomplished by the stimulation of vagal afferents.133
Sympathetic modulation of immunity: Relevance to disease
2008, Cellular Immunology
- ☆
This work was supported by grants from the USDHS, The RJR Nabisco Corporation, the MRC of Canada. AHG is a Terry Fox Scientist of the National Cancer Institute of Canada.
- 2
Current Address: Department of Psychology, University of Newcastle, Shortland, 2308 Australia.
- 3
Current Address: Department of Pathology, 236 Basic Medical Sciences Bldg., University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada, R3E OW3.