Elsevier

Comprehensive Psychiatry

Volume 25, Issue 1, January–February 1984, Pages 32-37
Comprehensive Psychiatry

Antipsychotic drug use and birth defects: An epidemiologic reassessment

https://doi.org/10.1016/0010-440X(84)90019-1Get rights and content

Abstract

A reassessment of studies concerned with the possible teratogenic effect of neuroleptic medication using the test-based approach of Miettinen suggests a possible increase in birth defects among children born of mothers first exposed to drugs during the sixth to tenth week of gestation. In view of the epidemiologic inadequacies of earlier studies which suggest no increased teratogenic effect of these drugs, caution should be used in their prescription during this stage of gestation. Further work is indicated using appropriate epidemiological techniques and multivariate statistical methodology to determine the true effect of these drugs in pregnant psychotic women.

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