Morphine: Effects on serotonergic neurons and neurons in areas with a serotonergic input
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Contributions of serotonin in addiction vulnerability
2011, NeuropharmacologyCitation Excerpt :The literature describing opioid effects on 5-HT neurotransmission contains conflicting findings. Some early studies suggested that morphine enhances 5-HT synthesis, release and metabolism in several brain regions (Smialowska and Bal, 1984; Spampinato et al., 1985; Rivot et al., 1989) but others have found an inhibitory effect of morphine on the firing rate of 5-HT cells in the raphe nuclei (Haigler, 1978; Alojado et al., 1994). Opioid-5-HT interactions are complex in part because different receptor subtypes mediate distinct effects on 5-HT.
Differential effects of chronic antidepressant treatments on μ- and δ-opioid receptors in rat brain
2002, European Journal of PharmacologyMorphine induces an increase in extracellular serotonin in the rat diencephalon
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