Functional postsynaptic α2- but not α1-adrenoceptors in dog saphenous vein exposed to phenoxybenzamine

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Abstract

Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenozybenzamine-resistant responses to clonidine were not affected by prazosin or by corynanthine but were competively antagonized by yohimbine (pA2 8.2). It is concluded that exposure of saphenous vein to phenoxybenzamine resulted in blockade of α1-adrenoceptors to the extent that there remained a virtually homogeneous population of postsynaptic α2-adrenoceptors. The effects of agents at postsynaptic α2-adrenoceptors can be studied on this preparation without the complications caused by the presence of functional α1-adrenoceptors.

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