Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics
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TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward
2019, Pharmacology and TherapeuticsCitation Excerpt :These studies may provide important information that may help the interpretation of current TSPO-PET findings. As far back as 1986, there were studies examining the levels of TSPO in platelets from schizophrenia subjects (Gavish et al., 1986; Weizman et al., 1986). Two different studies showed that the maximal number of [3H]PK11195 binding sites (Bmax) in platelets from untreated schizophrenia subjects did not differ from age-matched healthy controls.
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
2017, Neuroscience and Biobehavioral ReviewsPharmacological characterization of senktide-induced tail whips
2010, NeuropharmacologyCitation Excerpt :However, antipsychotics may work indirectly at these receptors, as several reports show alterations in GABAA following chronic treatment with antipsychotics in rodents (Dean et al., 2001; Skilbeck et al., 2007). Furthermore, alterations in binding are also seen in schizophrenic patients, both in platelets (Gavish et al., 1986) and in post-mortem brain tissue (Benes et al., 1996; Deng and Huang, 2006; Newell et al., 2007; Pandey et al., 1997). It is unknown whether the pharmacologically induced tail whips seen in the present study actually represent aggressive and threat behaviors, as tail whips do in natural settings.
Effects of long-term low-dose hormone replacement therapy on the binding capacity of platelet peripheral-type benzodiazepine receptor in postmenopausal women
2008, PsychoneuroendocrinologyCitation Excerpt :All other chemicals were of reagent grade or better and obtained from normal commercial sources. The preparation of samples was performed as described previously (Gavish et al., 1986). Blood samples (10 ml) were obtained from women in two groups on the same day, collected into plastic tubes containing K2EDTA as the anticoagulant, and spun at 1000 rpm for 15 min at 4 °C.
Psychiatric disorders
2007, Platelets