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Neuromedin U octapeptide alters ion transport in porcine jejunum

https://doi.org/10.1016/0014-2999(88)90415-3Get rights and content

Abstract

The gut neuropeptide, neuromedin U octapeptide (NMU-8) produced transient elevations in short-circuit current (EC50 = 0.7 nmol/1) after its contraluminal administration to sheets of porcine distal jejunal mucosa in vitro. Mucosal responses to NMU-8 were unaffected by 1 μmol/1 atropine or hexamethonium, but were abolished by tetrodotoxin (0.1 μmol/l), dependent upon extracellular Cl, and underwent tachyphylaxis upon repeated peptide application. NMU-8 did not affect contractility of isolated jejunal longitudinal muscle. Thus, NMU-8 appears to selectively modify intestinal ion transport through interactions with non-cholinergic enteric neurons.

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