Short communicationNeuromedin U octapeptide alters ion transport in porcine jejunum
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Cited by (68)
Distribution of neuromedin U (NMU)-like immunoreactivity in the goldfish brain, and effect of intracerebroventricular administration of NMU on emotional behavior in goldfish
2022, PeptidesCitation Excerpt :Subsequently, the NMU receptor was also identified, and shown to be a G protein-coupled receptor [5,6]. NMU is a multifunctional functional bioactive peptide involved in regulation of not only smooth muscle contraction, but also blood pressure, ion transport in the gut, mesenteric blood flow, adrenocortical function, energy balance and behavior [7–12]. Intracerebroventricular (ICV) administration of NMU or its related neuropeptide, neuromedin S (NMS) affects food intake and body weight [13,14] in rats, and hypothalamic expression of NMU mRNA changes according to feeding status in rats [6].
Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion
2019, Diabetes Research and Clinical PracticeCitation Excerpt :NMUR1 is expressed in mainly peripheral tissues, particularly the gastrointestinal tract, immune system, and pancreas [9–11], whereas NMUR2 is abundant in the hypothalamus, hippocampus, and spinal cord [7–9,12]. It has been reported that NMU could play a role in energy homeostasis and in a wide variety of other physiological processes, including blood pressure, smooth muscle contraction, nociception, stress and inflammation [4,13–17]. NMU administration has been shown to decrease food intake and body weight in rodents by increasing energy expenditure, locomotor activity and oxygen consumption [5,18–20].
Identification and immunoregulatory function of neuromedin U (Nmu) in the Japanese pufferfish Takifugu rubripes
2017, Developmental and Comparative ImmunologyNeuromedin: An insight into its types, receptors and therapeutic opportunities
2017, Pharmacological ReportsDesign, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor
2014, Bioorganic and Medicinal Chemistry