Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons

doi:10.1016/0014-2999(89)90031-9

European Journal of Pharmacology

Volume 169, Issues 2–3, 10 October 1989, Pages 321-324

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Abstract

The acute administration of GR38032F, a selective 5-HT₃ receptor antagonist, did not change the concentrations of dopamine (DA) or 5-hydroxytryptamine (5-HT) or their deaminated metabolites in nucleus caudatus, nucleus accumbens or substantia nigra. Pretreatment with GR38032F failed to modify the haloperidol-induced activation of DA turnover. It is concluded that the blockade of central 5-HT₃ receptors by GR38032F under these experimental conditions does not result in alternations in metabolism of DA or 5-HT in major ascending dopaminergic areas.

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Short communicationEffects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons

Abstract

European J. Pharmacol.

European J. Pharmacol.

Brain Res.

European J. Pharmacol.

European J. Pharmacol.

Short communication
Effects of acute GR38032F (odansetron), a 5-HT₃ receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons