Short communicationPeripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats
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Cited by (110)
Role of peripheral 5-HT<inf>1D</inf>, 5-HT<inf>3</inf> and 5-HT<inf>7</inf> receptors in the mechanical allodynia induced by serotonin in mice
2021, Biomedicine and PharmacotherapySerotonin and nociception: From nociceptive transduction at the periphery to pain modulation from the brain
2019, The Serotonin System: History, Neuropharmacology, and PathologyPotential functional and pathological side effects related to off-target pharmacological activity
2017, Journal of Pharmacological and Toxicological MethodsSerotonin induces peripheral mechanical antihyperalgesic effects in mice
2015, European Journal of PharmacologyCitation Excerpt :Several studies have helped to elucidate the role of pro-nociceptive 5-HT when administered peripherally in humans (Jensen et al., 1990) and in rats by activation of 5-HT1, 5-HT2 and 5-HT3 receptors. In addition, endogenous 5-HT produced in situ, is involved in the nociceptive response induced by formalin inflammation in the rat paw, possibly via 5-HT3 receptors (Giordano and Rogers, 1989; Parada et al., 2001). In our experiments injection of serotonin in various doses, induced the peripheral mechanical antihyperalgesic effect.
Serotonin enhances urinary bladder nociceptive processing via a 5-HT<inf>3</inf> receptor mechanism
2015, Neuroscience LettersCitation Excerpt :However, a number of studies suggest that activation of peripheral 5HT3 receptors induces pro-nociceptive effects. Local administration of 5HT3 receptor antagonists have been shown to be analgesic in acute and chronic pain [30], and in a model of persistent temporomandibular joint inflammation [31]. In humans, topical ondansetron attenuates the nociceptive and inflammatory effects of intradermal capsaicin [32].
The anti-inflammatory effects of the 5-HT <inf>3</inf> receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes
2012, International ImmunopharmacologyCitation Excerpt :But also experimental studies suggest that 5-HT3 receptor antagonists possess both an analgesic and an antiphlogistic effects. Experimentally induced acute and chronic inflammatory pain [11–14] as well as chemically induced pain [15,16] responded well to 5-HT3 receptor antagonists, probably because the latter inhibit nociceptor stimulation. 5-HT3 receptors occur mainly in the peripheral nervous system, particularly on nociceptive sensory neurons, and on autonomic and enteric neurons, on which serotonin (5-HT) exerts a strong excitatory effect [17].