Behavioural changes in the offspring of rats exposed to diazepam during gestation
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Cited by (31)
Effects of Cannabinoids on Rat Development and Emission of Ultrasonic Vocalizations
2018, Handbook of Behavioral NeuroscienceCitation Excerpt :Moreover, the benzodiazepine gamma-aminobutyric acid (GABA) receptor chloride complex plays a crucial role in the physiologic mediation of ultrasonic emissions (Cagiano et al., 1990). In this regard, we demonstrated that infant rats prenatally exposed to the benzodiazepine derivative, diazepam, showed alterations in the duration of USVs elicited by removal from their nest (Cagiano et al., 1990). Moreover, it has been observed that diazepam and chlordiazepoxide influence ultrasonic calls in rat pups subjected to an unavoidable stressful stimulus (Gardner, 1985).
Risk mitigation for children exposed to drugs during gestation: A critical role for animal preclinical behavioral testing
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Data for children tracked into adulthood were not available. Prenatal exposure on the last week of gestation was associated with deficits in learning, decreases in locomotor and exploratory activity (anxiety) and an increase in the acoustic startle response (attention) in adulthood (Cannizzaro et al., 2005); similar exposure impaired male sexual behavior (Cagiano et al., 1990), enhanced aggression (social behavior; Singh et al., 1998), and either increased or decreased OFT ambulation and tunnel-board exploratory activity (complementary measures of exploratory anxiety), and reduced zero-maze activity (anxiety) and social interactions (Lall and Sahoo, 1990; Singh et al., 1996; social behavior). Prenatal exposure decreased freezing behavior and improved performance in the active avoidance test and did not affect swimming navigation in adulthood (learning; Driscoll et al., 1995) but in another study induced significant deficits in acquisition and retention of a spatial discrimination learning test (Jaiswal and Bhattacharya, 1993).
Vitamin A supplementation in rats under pregnancy and nursing induces behavioral changes and oxidative stress upon striatum and hippocampus of dams and their offspring
2011, Brain ResearchCitation Excerpt :One of the most traditional and widely used methods for the assessment of the locomotive and explorative behavior as well as the emotional state in rodents is the OFT, which plays many varieties (Tobach, 1969; Prut and Belzung, 2003). Because it is a relatively simple technique and gives quantitative information on a broad range of responses, it has been frequently used in teratologic studies (Cagiano et al., 1990; Di Giovanni et al., 1993). The OFT apparatus consists of a circular arena surrounded by 40-cm high walls.
Perinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring
2005, Pharmacology Biochemistry and BehaviorEffects of maternal exposure to picrotoxin during lactation on physical and reflex development, square crossing and sexual behavior of rat offspring
2003, Pharmacology Biochemistry and BehaviorLong-lasting behavioral changes induced by pre- or neonatal exposure to diazepam in rats
2003, European Journal of Pharmacology