5-HT receptors mediating contractions of the isolated human coronary artery
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Migraine
2022, Comprehensive PharmacologyPharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels
2000, European Journal of PharmacologyCitation Excerpt :The exact nature of this additional mechanism involved in eletriptan-induced contraction is unknown, but it is conceivable that a part of the contraction to high concentrations of eletriptan, particularly after blockade of the 5-HT1B receptor by GR125743, may be mediated via the 5-HT2A receptor. In contrast to the human middle meningeal artery that predominantly possesses 5-HT1B receptor population (Jansen et al., 1992; Razzaque et al., 1999), it is known that both human coronary artery and saphenous vein have a mixed population of 5-HT1B and 5-HT2 receptors (Connor et al., 1989; Bax et al., 1992, 1993; Ishida et al., 1999; Nilsson et al., 1999b). We must, however, concede that eletriptan does not differ from sumatriptan with regard to the affinity at the 5-HT2A receptor (pKi: both <5.5, Napier et al., 1999).
The effect of Sumatriptan in ischemic conditions in the rat heart
2018, Turkish Journal of Pharmaceutical Sciences