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Galantide stimulates sexual behavior in male rats

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Abstract

While intracerebroventricular injection of galanin (5 μg/rat) inhibited sexual behavior in experienced male rats - without producing any other locomotor or behavioral deficit -, injection of the galanin antagonist, galantide, by the same route (1 or 2 μg/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. These data further suggest that galanin plays a physiological role in male sexual behavior.

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    Citation Excerpt :

    Galanin, like neuropeptide Y, is highly concentrated in the hypothalamus, the amygdaloid complex and the brainstem and coexists with several neurotransmitters and neuropeptides (for a review see Bartfai, 1995), increases feeding when injected into the PVN (see Crawley et al., 1990 and references therein) and inhibits sexual behaviour of sexually active male rats when given into the lateral ventricles (Poggioli et al., 1992). Accordingly, galantide, a putative galanin receptor antagonist, given into the lateral ventricles facilitates male sexual behaviour (Benelli et al., 1994a). At variance from the above studies, galanin injected into the sexually dimorphic medial preoptic nucleus facilitates male and female sexual behaviour in the rat (Bloch et al., 1993, 1996).

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