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P2 purinoceptors modulating noradrenaline release from sympathetic neurons in culture

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Abstract

ATP (1 mM) inhibited, whereas 2-methylthio-ATP (30 μM), a P2Y-selective purinoceptor agonist, increased electrically evoked release of [3H]noradrenaline from chick sympathetic neurons. The P2X-selective purinoceptor agonist α,β-methylene-ATP (30 μM) had no effect. The ATP-induced inhibition of release as well as the facilitation caused by 2-methylthio-ATP was not affected by the selective adenosine (P1) receptor antagonist 8-(p-sulfophenyl)-theophylline (8-PST; 100 μM), but completely prevented by the non-selective P2 antagonist suramin (300 μM). The present data reveal a dual regulation of noradrenaline release from sympathetic neurons. Facilitation seems to be mediated by a P2Y purinoceptor, whereas inhibition is caused by a P2 purinoceptor which needs further subtype characterization.

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