Short communicationSensitivity of histamine H3 receptor agonist-stimulated [35S]GTPγ[S]binding to pertussis toxin
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Histaminergic effects on the frequency of repetitive spike firing in rat insular cortex
2012, Neuroscience LettersCitation Excerpt :Intracellular recordings using slice preparations demonstrate that H2 receptors, coupling to Gs protein, increase the frequency of repetitive spike firing of cortical neurons by blocking Ca2+-dependent K+ channels that regulate afterhyperpolarization (AHP) [12,13]. In contrast to the studies of H2 receptors in the cerebral cortex, little information is available regarding the functional roles of H3 receptors [16], which decrease cyclic-3′,5′-adenosine monophosphate (cAMP) concentration and Ca2+ conductance by activating Gi/o protein [3] and regulate neural firing, histamine synthesis and release of histamine as autoreceptors [6,15,19,21]. Taking into account the finding that H3 receptors are highly expressed in the cerebral cortex [4,11,16], there is a possibility that H3 receptors affect neural functions, including the action potential properties in the IC.
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