Mitogenicity of thrombin and surface alterations on mouse splenocytes☆
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Protease-activated receptors in hemostasis, thrombosis and vascular biology
2005, Journal of Thrombosis and HaemostasisRoles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo
2002, BloodCitation Excerpt :Thus, although thrombin is not absolutely required for cytokine/chemokine production in response to antigen or LPS, thrombin clearly has the capacity to stimulate secretion of inflammatory mediators in vivo in a fibrin(ogen)-dependent manner. In vitro, thrombin reportedly stimulates leukocyte chemotaxis68-70 and proliferation,71-73 and activates mast cell degranulation.74 In theory, gene-targeting techniques could provide an unambiguous means to study inflammatory roles for thrombin in vivo.
Human ovarian follicular fluid has functional systems for the generation and modulation of thrombin
2000, Fertility and SterilityThrombin is a novel regulator of hexokinase activity in mesangial cells
2000, Kidney InternationalCitation Excerpt :In addition to its central role in hemostasis, thrombin regulates a number of important cellular responses to vascular injury, including cell growth, cell migration, and matrix accumulation. Although best characterized in platelets34,35 and in vascular endothelial cells36, thrombin's cellular actions have been demonstrated in a variety of other cell types37-40, including glomerular mesangial cells30,33,41-43. These diverse cellular effects require thrombin's proteolytic activity and are largely mediated by specific interaction with one or more recently identified members of the protease-activated receptor family (PARs).
Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptor
1998, Journal of Biological Chemistry
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This work was supported by grant CA02015 of the NCI, NIH to John M. Buchanan.
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Lan Bo Chen is a predoctoral fellow of Johnson & Johnson Associate Industries Fund.
- 1
Nelson N. H. Teng is a postdoctoral fellow of the Muscular Dystrophy Association.