Self-stimulation and alcohol administered orally or intraperitoneally
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2014, European NeuropsychopharmacologyCitation Excerpt :Enhanced brain reward function by acute ethanol in mice (e.g., Fish et al., 2012) and selectively bred alcohol-preferring rats (Eiler et al., 2007) may not generalize to outbred rat strains. Additionally, some studies used uncommon ICSS procedures (Lewis and June, 1990, 1994; Musgrave et al., 1989) or inferred reward enhancement from increased response rates (rate–frequency procedures; Bain and Kornetsky, 1989; de Witte and Bada, 1983). In the present study, we assessed the effects of ethanol on brain reward function using the rate-free discrete-trial current-threshold procedure (Kornetsky et al., 1979; Markou and Koob,1992).
Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats
1999, European Neuropsychopharmacology
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