Cardiovascular and renal effects of urotensins I and II in the eel, Anguilla rostrata☆

https://doi.org/10.1016/0016-6480(75)90052-0Get rights and content

Abstract

Chromatographically pure urotensin I and II fractions were tested in the unrestrained concious eel, Anguilla rostrata, for their vascular and renal effects. Urotensin I exerted mild pressor effects, increased urine flow, and Ca2+ and Mg2+ excretion but did not affect inulin clearance rates. Urotensin II was also hypertensive being more potent (on the UHS unit basis) than urotensin I. It also stimulated the caudal lymph heart, elevated caudal venous pressure, and increased inulin clearance and urine flow. The findings suggest that urotensin I and II may act as separate hormones in the eel.

References (44)

  • K. Lederis

    Teleost urophysis. I. Bioassay of an active urophysial principle on the isolated urinary bladder of the rainbow trout, Salmo gairdnerii

    Gen. Comp. Endocrinol

    (1970)
  • J. Maetz et al.

    Urophyse et osmorégulation chez Carassius auratus

    Gen. Comp. Endocrinol

    (1964)
  • J. Maetz et al.

    Peptide neurohypophysaires et osmorégulation chez Carassius auratus

    Gen. Comp. Endocrinol

    (1964)
  • N. Takasugi et al.

    Experimental studies of the caudal neurosecretory system of Tilapia mossambica

    Comp. Biochem. Physiol

    (1962)
  • K. Yagi et al.

    Electrophysiological analysis of the response of the caudal neurosecretory system of Tilapia mossambica to osmotic manipulations

    Gen. Comp. Endocrinol

    (1965)
  • P.R. Zelnik et al.

    Chromatographic separation of urotensins

    Gen. Comp. Endocrinol

    (1973)
  • M.M. Babiker et al.

    Effects of neurohypophysial hormones on renal function in the freshwater- and seawater-adapted eel (Anguilla anguilla L.)

    J. Endocrinol

    (1973)
  • A. Berlind

    Teleost caudal neurosecretory system: sperm duct contraction induced by urophysial material

    J. Endocrinol

    (1972)
  • H.A. Bern et al.

    A reference preparation for the study of active substance in the caudal neurosecretory system of teleosts

    J. Endocrinol

    (1969)
  • H.A. Bern et al.

    The structure and function of the caudal neurosecretory system of fishes

    Arch. Anat. Microsc. Morphol. Exp

    (1965)
  • H.A. Bern et al.

    Occurrence of urotensin II (bladder-contracting activity) in the caudal spinal cord of anamniote vertebrates

    Acta Zool

    (1973)
  • D.K.O. Chan

    Hormonal regulation of cardiac output and regional blood flow in the eel, Anguilla japonica

    Gen. Comp. Endocrinol

    (1969)

    • Cited by (0)

    ☆

    A report based on this paper was given at the Seventh Symposium on Comparative Endocrinology, Tsavo National Park, Kenya, in July 1974.

    2

    Permanent address: Department of Zoology, University of Hong Kong.

    View full text
    Copyright © 1975 Published by Elsevier Inc.