Research paperReduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis☆
References (25)
- et al.
Methionine intolerance: a possible risk factor for coronary artery disease
J. Amer. Coll. Cardiol.
(1985) - et al.
Homocysteine content of plasma proteins in ischemic heart disease
Atherosclerosis
(1988) - et al.
Effect of vitamin B6 depletion in adult man on the excretion of cystathionine and other methionine metabolites
J. Nutr.
(1970) - et al.
Homocysteinemia due to folate deficiency
Metabolism
(1987) - et al.
The interaction of human plasma glycosaminoglycans with plasma lipoproteins
J. Biol. Chem.
(1975) - et al.
Recent advances in molecular pathology. Carbohydrate-protein macromolecules and arterial wall integrity — A role in atherosclerosis
Exp. Mol. Pathol.
(1984) The reaction of homocysteine with aldehydes — An explanation of the collagen defects in homocystinuria
Clin. Chim. Acta
(1973)- et al.
The pathogenesis of coronary artery disease: A possible role for methionine metabolism
J. Clin. Invest.
(1976) - et al.
Moderate homocysteinemia — a possible risk factor for arteriosclerosic cerebrovascular disease
Stroke
(1984) - et al.
Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease
New Engl. J. Med.
(1985)
Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease
J. Clin. Invest.
The role of homocysteine in the pathogenesis of arteriosclerosis
Cited by (70)
Phosphorylation of GSK-3β and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium
2015, European Journal of PharmacologyCitation Excerpt :Troxerutin or vitamin P4, is a flavonoid that can be found in tea, coffee, cereal and a variety of fruits and vegetables. This flavonoid has attracted much attention due to its pharmacological properties such as significant anti-inflammatory, antioxidant, and anti-thrombolytic activities (Blasig et al., 1988; Heidarzadeh et al., 2014; Olszewski et al., 1989). Previous experiments have also confirmed the tissue protective effect of troxerutin in kidney (Shao-hua et al., 2009), liver (Zhang et al., 2009) and brain (Lu et al., 2010, 2011) injuries.
Hyperhomocysteinemia induced by feeding rats diets rich in dl-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure
2009, Vascular PharmacologyCitation Excerpt :This is an important observation since it allowed us to compare the effects of the time–course treatment with homocysteine on the vascular functionality and morphology, further discarding the influence of the plasma level of homocysteine in this response. A positive correlation between plasma levels of homocysteine and cholesterol has been found in patients with HHcy as well as in experimental animals (Olszewski et al., 1989; McCully et al., 1990). The accumulation of lipids in the arterial wall, particularly cholesterol, is a major event preceding the formation of atherosclerotic lesions (Raines and Ross, 1993; Nordestgaard, 1996).
Effectiveness of ezetimibe in routine clinical practice. Effect on lipid profile and other laboratory parameters
2008, Endocrinologia y NutricionMedical management of peripheral arterial disease
2005, Journal of Thrombosis and HaemostasisElevated plasma homocysteine as risk factor for peripheral arterial disease - What is the evidence?
2003, Seminars in Vascular Surgery
- ☆
Supported by National Grant KPBR MZ 09 from the Polish Ministry of Health.