Journal of Molecular Biology
Letter to the editorMyosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing☆
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2013, Journal of Sexual MedicineCitation Excerpt :Myosin, the molecular motor of contraction, is a hexamer consisting of two heavy chains (myosin heavy chain [MHC]), two phosphorylatable 20 kDa light chains and two 17 kDa essential light chains. Four isoforms of smooth muscle (SM) MHC are formed by alternative splicing of a single gene [11-13]. Alternative splicing at the 5′ end of pre‐mRNA forms two isoforms (SM‐A, SM‐B) of MHC that differ in their amino‐terminal sequence [11,13,14].
Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure
2011, Archives of Biochemistry and BiophysicsCitation Excerpt :Each smooth muscle myosin II molecule consists of: (i) two myosin heavy chains (MHC) that have intertwined coiled-coil tail sequences and N-terminal globular enzymatic heads; and (ii) two pairs of associated 20 kDa LC20 and 17 kDa essential light chains that localize to neck region of each MHC (Fig. 2). Four distinct isoforms (1A & 1B, 2A & 2B) of smooth muscle myosin II are expressed in a tissue- and developmental stage-dependent manner owing to alternate splicing of the single myosin gene at two sites within the C- (isoforms 1 and 2) and N- (isoforms A and B) terminal regions [15,16]. The MHC-1 and -2 variants have different C-terminal tails of 43 versus 9 residues in length, respectively, that influence the thick filament organization and, thereby, the minimal cell length that can be achieved during contraction [17], but not the kinetics of shortening (i.e. cross-bridge cycling rate and shortening velocity are similar in in vitro motility assays [14,18]).
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This work was supported by NIH grant R29-38355.