Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals—A genetic study
References (28)
- et al.
The effect of drugs on the concentration of dopamine-β-hydroxylase in the cerebrospinal fluid of rabbits
Neuroscience
(1980) - et al.
Human platelet MAO—a useful enzyme in the study of psychiatric disorders?
Neuroscience
(1982) - et al.
Dopamine-β-hydroxylase and norepinephrine in human cerebrospinal fluid: effects of monoamine oxidase inhibitors
Neuropharmacology
(1979) - et al.
Genetic control of plasma dopamine-β-hydroxylase
Life Sci.
(1973) - et al.
Dopamine β-hydroxylase in hypertension
Acta med. scand.
(1974) - et al.
Genetically determined differences in noradrenergic input to the brain cortex: a histochemical and biochemical study in two inbred strains of mice
Neuroscience
(1979) - et al.
The interactions of smoking, environment and heredity and their implications for disease etiology
Acta med. scand.
(1977) - et al.
Studies on similarity diagnosis in twins with the aid of mailed questionnaires
Acta Genet. med. Gemell.
(1961) Genetic regulation of the catecholamine synthesizing enzymes: relationships to behaviour and psychiatric disturbances
- et al.
Pentametric distribution of platelet monoamine oxidase activity
Psychiat. Res.
(1985)
Regional brain norepinephrine turnover in four strains of mice
Neuroendocrinology
Brain serotonin content: physiological regulation by plasma neutral amino acids
Science
Platelet monoamine oxidase activity in sensation seekers
Psychiat. Res.
Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based on psychiatric interviews
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Genetic, epigenetic, and environmental factors in serotonin-associated disease condition
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :Genetic, epigenetic, and environmental factors contribute to central serotonin turnover as assessed by the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) (Clarke et al., 1996; Higley et al., 1991, 1993; Oxenstierna et al., 1986). Serotonin turnover rates can be measured in vivo in nonhuman primates, and heritability estimates of serotonin turnover accounted for 42% of the variance (Kaplan, 2000), a number that is rather close to heritability estimates in human twin studies, which accounted for about 35% of the variance in CSF 5-HIAA concentrations; therefore, epigenetic and environmental factors appear to play a predominant role in the regulation of central serotonin turnover (Beck et al., 1984; Oxenstierna et al., 1986). Environmental factors are of special interest if they have long-lasting effects on serotonergic neurotransmission, and such lasting effects were observed following developmentally early social separation stress (Clarke et al., 1996; Higley et al., 1991; Jones, Hernandez, Kendall, Marsden, & Robbins, 1992) with implications for hippocampal volume changes (Coplan et al., 2014).
Association between DBH 19 bp insertion/deletion polymorphism and cognition in schizophrenia with and without tardive dyskinesia
2017, Schizophrenia ResearchCitation Excerpt :Moreover, previous studies have found that DBH is involved in the regulation of mood and attention functions (Hamner and Gold, 1998; Bellgrove et al., 2006). Additional studies have found that schizophrenia with TD is associated with low DBH activity which is under strong DBH genetic control (Weinshiboum, 1978; Jeste et al., 1981; Wagner et al., 1982; Goldin et al., 1982; Kaufman et al., 1986; Oxenstierma et al., 1986; Cubells et al., 2011). These results suggested that cognitive function might be influenced by the DBH gene that encodes the rate-limiting enzyme for the conversion of DA to NE in schizophrenia with TD.
Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males
2016, Progress in Neuro-Psychopharmacology and Biological PsychiatryCerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis
2015, Psychiatry ResearchCitation Excerpt :In the present study, we have used the term intermediate phenotypes to characterize the monoamine metabolite concentrations relative to psychosis, as they have been reported to be heritable and to some extend psychosis-related, but do not formally fulfill all the endophenotype-related criteria required. Regarding heritability, a study in human twins has shown that CSF MHPG is under major genetic influence, whereas CSF 5-HIAA and HVA are under both genetic and environmental influence (Oxenstierna et al., 1986). Studies in other primates also indicate that monoamine metabolite CSF concentrations are partially under genetic influence (Higley et al., 1993; Rogers et al., 2004).
Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: Results from a large multicenter association study
2013, Drug and Alcohol DependenceCitation Excerpt :By use of both sequencing-based mutation analysis of extreme phenotypes and genotype–phenotype correlations in samples from African Americans, European Americans and Japanese, Zabetian et al. (2001) identified a novel polymorphism (−1021C-T; rs1611115) in the 5-prime flanking region of the DBH gene which accounts for 35–52% of the variation in plasma DBH activity in these populations. Variation in DBH activity both in serum and in CSF has been reported to be over 80% heritable (Oxenstierna et al., 1986). The single nucleotide polymorphism (SNP), −1021C/T (rs1611115), has been identified as the main predictor of DBH activity in plasma (Zabetian et al., 2001, 2003).