Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury
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2000, British Journal of AnaesthesiaCitation Excerpt :Other studies have used mast cell protease activity14 or tryptase release35 to demonstrate inhibition of mast cells by lodoxamide. Other actions of lodoxamide in the lung that may contribute to its anti-inflammatory behaviour include inhibition of xanthine oxidase36 and prevention of neutrophil accumulation.37 Of considerable clinical interest, in the context of lung transplantation, has been the finding that lodoxamide reduces lung injury after ischaemia and reperfusion38 and after re-expansion from a state of atelectasis.37
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2000, Journal of Laboratory and Clinical MedicineCitation Excerpt :These oxygen metabolites can then be further metabolized into other species, including the highly toxic hydroxyl radical. Lodoxamide and allopurinol have been used to inhibit xanthine oxidase and attenuate ischemic lung injury.95 Other additives have included superoxide dismutase, vasoactive intestinal peptide,96 and lazaroids.97