Recovery from peripheral nerve transection is accelerated by local application of α-MSH by means of microporous Accurel® polypropylene tubes
References (17)
- et al.
Effects of corticotropin (ACTH) on recovery of sensorimotor function in the rat - Structure-activity study
Europ. J. Pharmacol.
(1981) - et al.
The enhanced recovery of sensorimotor function in rats is related to the melanotropic moiety of ACTH/MSH neuropeptides
Europ. J. Pharmacol.
(1983) - et al.
Peripheral nerve reconnection - Mechanical, thermal and ionic conditions that promote the return of function
Exp. Neurol.
(1983) - et al.
Selected recent advances in peripheral nerve injury research
Surg. Neurol.
(1985) - et al.
Controlled long-term release of small peptide hormones using a new microporous polypropylene polymer - Its application for vasopressin in the Brattleboro rat and its potential perinatal use
J. Pharmaceut. Sci.
(1984) - et al.
An in vivo assay of neurotropic activity
Brain Res.
(1983) - et al.
ACTH accelerates recovery of neuromuscular function following crushing of peripheral nerve
Peptides
(1980) - et al.
Competence of nerve tissue as a distal insert promoting nerve regeneration in a silicone chamber
Brain Res.
(1984)
There are more references available in the full text version of this article.
Cited by (49)
Brain effects of melanocortins
2009, Pharmacological ResearchAccelerating sensory recovery after sciatic nerve crush: Non-selective versus melanocortin MC<inf>4</inf> receptor-selective peptides
2004, European Journal of PharmacologyCombined treatment with α MSH and methylprednisolone fails to improve functional recovery after spinal injury in the rat
2000, Brain ResearchCitation Excerpt :Further research has shown that the high doses of MP required to inhibit lipid peroxidation also exert a number of other actions on the injured spinal cord that almost certainly contribute to an attenuation of post-traumatic neuronal damage (e.g., reduction in ischemic area and neurofilament degradation, preserved evoked potentials and improved spinal cord blood flow) [10, 25, 43, 44]. Melanocortins, peptides related to melanotropin (αMSH) and adrenocorticotropin (ACTH), are known to improve axonal regeneration following sciatic nerve injury [6, 7, 17, 18, 21, 35–37, 42] and to enhance compensation after damage to the CNS [20, 40, 41]. In vitro, melanocortins also exert trophic effects on the outgrowth of neurites from CNS neurons [2, 39].
Melanocortin receptors mediate α-MSH-induced stimulation of neurite outgrowth in Neuro 2A cells
1996, Molecular Brain Research
Copyright © 1986 Published by Elsevier B.V.