Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in human CSF: Correlations with neurological disorders
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Cited by (30)
Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease
2011, Neurobiology of AgingCitation Excerpt :Our findings suggest that in early AD, there is an attempt to increase the biosynthesis of neurosteroids and neuroactive steroids through increased mitochondrial import of cholesterol. Previously, measurements of enzyme levels in cerebrospinal fluid (CSF) showed that DBI protein levels were increased in AD patients with severe cognitive impairment (Ferrarese et al., 1990) although other studies failed to find any increase (Barbaccia et al., 1986; Ferrero et al., 1988), a discrepancy which may be related to differences in AD cognitive impairment and age range of the subjects. Second, we found increased expression of AKR1C2 mRNA in PFC of AD patients starting from BR 3.
Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis
2011, NeuroscienceCitation Excerpt :DBI promotes the loading of cholesterol into the mitochondrion, which is a rate-limiting step for the whole neurosteroid biosynthetic pathway, and does so both directly and via interaction with TSPO. Previously, measurements of enzyme levels in cerebrospinal fluid (CSF) showed that DBI protein levels were increased in AD patients with severe cognitive impairment (Ferrarese et al., 1990) although other studies failed to find any increase (Barbaccia et al., 1986; Ferrero et al., 1988), a discrepancy which may be related to differences in the degree of cognitive impairment and the age range of the subjects. StAR protein was also markedly increased in both the cytoplasm of hippocampal pyramidal neurons and in the cytoplasm of other non-neuronal cell types in the brains of female AD patients, when compared with age-matched controls (Webber et al., 2006).
Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach
2010, Neurobiology of DiseaseCitation Excerpt :Cell death may on the other hand result in increased levels of neuropeptides through the release of peptides from damaged brain tissue (Espino et al., 1995). Raised CSF peptide levels have been demonstrated for diazepam binding inhibitor (DBI) (Ferrero et al., 1988a,b) and des-ala-somatostatin (Strittmatter et al., 1996). Several neuropeptides have been reported only once and the results of some neuropeptide studies led to conflicting data (Dupont et al., 1982; Espino et al., 1995; Jolkkonen et al., 1986; Strittmatter et al., 1996; Strittmatter and Cramer, 1992; Unger et al., 1988).
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning
2007, Molecular and Cellular NeuroscienceEffect of diazepam binding inhibitor (DBI) on the fluid intake, preference and the taste reactivity in mice
2001, Behavioural Brain Research