MinireviewA functional basis for classification of α-adrenergic receptors
References (57)
Am. J. Physiol.
(1948)- et al.
Nature
(1967) - et al.
Circ. Res.
(1976) J. Pharmac. Exp. Ther.
(1976)Biochem. Pharmacol.
(1976)- et al.
Naunyn-Schmiedeberg's Arch. Pharmacol.
(1975) - et al.
Archs Int. Pharmacodyn. Ther.
(1972) Eur. J. Pharmacol.
(1976)Br. J. Pharmacol.
(1973)Frontiers in Catecholamine Research
Acta. Physiol. Scand.
J. Pharmacol. Exp. Ther.
J. Physiol. Lond.
Neuropharmacology
Naunyn-Schmiedeberg's Arch. Pharmacol.
J. Invest. Dermatol.
Endocrinology
Circ. Res.
Circ. Res.
Am. J. Cardiol.
Ann. Rev. Pharmacol.
J. Pharm. Pharmacol.
Neuropharmacology
Arzneim-Forsch
Life Sci.
J. Pharm. Pharmacol.
Naunyn-Schmiedeberg's Arch. Pharmacol.
Neuropharmacology
Cited by (700)
Localization and neurochemical identity of alpha1-adrenergic receptor-containing elements in the mouse locus coeruleus
2023, Journal of Chemical NeuroanatomyImpairment of natriuresis and diuresis induced by intrarenal adrenoceptor mechanisms in an experimental model of cirrhosis in rats
2019, HeliyonCitation Excerpt :They found that in cirrhotic patients with renal impairment, unilateral lumbar sympathetic blockade with an anesthetic agent induced a significant improvement in renal function, leading to an increase in GFR and RPF [5]. It has been described that sympathetic activation of the kidney produces an increase in sodium reabsorption and either an increase or a decrease in renal vascular resistance in response to activation of alpha-1 or alpha-2 adrenoceptors, respectively [6, 7]. Indeed, previous studies have shown that the antinatriuresis elicited by renal nerve stimulation was blocked by previous intrarenal administration of alpha-1 adrenoceptor antagonists but not by alpha-2 antagonists [8, 9].
β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility
2019, Molecular and Cellular EndocrinologyCitation Excerpt :NE and/or Epi are implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors. Based on pharmacological and molecular evidence, adrenergic receptors (ADRs) are classified into three major types: α1, α2 and β, each of which is further divided into at least three subtypes (α1A, α1B, α1D; α2A, α2B, α2C; β1, β2, and β3) (Ahlquist, 1966; Berthelsen and Pettinger, 1977; Fraser and Venter, 1980; Emorine et al., 1989). Different ADRs have been localized to several testicular cells.
The pharmacology of α<inf>1</inf>-adrenoceptor subtypes
2019, European Journal of PharmacologyCitation Excerpt :The Ahlquist classification was further expanded by the subdivision of β-adrenoceptors into 2 subtypes, mainly on the affinities of adrenaline and noradrenaline: β1-and β2-adrenoceptors (Lands et al., 1967) (see Fig. 1). The next major expansion in α-adrenoceptor subclassification came when α2-adrenoceptors were identified, initially as presynaptic or prejunctional inhibitory receptors (see Langer, 1974; Starke, 1977), and subsequently also as postjunctional receptors on smooth muscle (Berthelsen and Pettinger, 1977) (see Fig. 1). In hindsight, we can see that Ahlquist's classification already pointed to the division of α-adrenoceptors into α1- (excitatory) and α2-adrenoceptors (inhibitory to intestine by prejunctional actions) (see Fig. 1).