Elsevier

Life Sciences

Volume 22, Issue 7, February 1978, Pages 619-623
Life Sciences

Self-administration of heroin, acetylmethadol, morphine, and methadone in rhesus monkeys

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Abstract

Heroin, α-l-acetylmethadol (LAAM), morphine, and methadone each maintained self-administration in rhesus monkeys. The order of relative potency was heroin ≥ LAAM > morphine ≥ methadone. Total daily drug intake increased as dose per injection increased; maximum daily intake was inversely related to relative potency. At high doses, self-injection of methadone and LAAM caused stupor and/or respiratory failure in some monkeys. These toxic effects were partly or completely reversible by naloxone.

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Supported in part by NIDA Contract HSM 42-72-167

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