Elsevier

Life Sciences

Volume 25, Issue 26, 24 December 1979, Pages 2149-2162
Life Sciences

Current concepts
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

https://doi.org/10.1016/0024-3205(79)90087-0Get rights and content

Abstract

The hypothesis that brain noradrenergic systems have a broad biological function which is related to human fear or anxiety is reviewed. Data from studies of the function of the nucleus locus coereleus in non-human primates are presented in the context of recent anatomical, physiological, pharmacological, and animal behavioral experiments. Implications are suggested for the treatment of anxiety, drug addictions, pain, and psychosomatic diseases.

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