Bivalent opioid peptide analogues with reduced distances between pharmacophores
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The opioid peptide biphalin modulates human corneal epithelial wound healing in vitro
2021, Journal Francais d'OphtalmologieThe neuroprotective role of the brain opioid system in stroke injury
2018, Drug Discovery TodayBiphalin preferentially recruits peripheral opioid receptors to facilitate analgesia in a mouse model of cancer pain - A comparison with morphine
2016, European Journal of Pharmaceutical SciencesCitation Excerpt :Moreover, the lack of cross-tolerance to biphalin reported in experiments involving morphine-tolerant DRGs points to the potential relevance of other opioid receptor subtypes (Shen and Crain, 1995). The involvement of κ-opioid receptors was proposed after an observation describing that higher doses of biphalin co-injected with ketamine provoke a slower onset of tolerance in vivo (Kosson et al., 2008; Lipkowski et al., 1987). A similar mechanism was proposed for opioid-induced dependence, where biphalin showed considerably less withdrawal symptoms in rats than morphine (Yamazaki et al., 2001).
Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)
2016, NeuropharmacologyCitation Excerpt :The neuroprotective action of biphalin seen 7 days after trauma is manifested in behavioral tests as an improvement of cognitive function and on the cellular level by reduction of neuronal damage. Biphalin was primarily designed as a potent nonspecific opioid analgesic that might in the future broaden the choice range of painkilling drugs (Lipkowski et al., 1982, 1987; Horan et al., 1993). Our results confirming the promising neuroprotective effects of biphalin add a new favorable characteristic to the possible first-line treatment of mTBI patients experiencing pain as a result of an accident.
Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands
2015, British Journal of Anaesthesia