Pharmacology letterIdentification of a human delta opioid receptor: Cloning and expression
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Cited by (132)
Targeting opioid dysregulation in depression for the development of novel therapeutics
2019, Pharmacology and TherapeuticsCitation Excerpt :Initially isolated from mouse vas deferens (Lord, Waterfield, Hughes, & Kosterlitz, 1977), the DOR was the first opioid receptor to be sequenced (Evans, Keith Jr., Morrison, Magendzo, & Edwards, 1992; Kieffer, Befort, Gaveriaux-Ruff, & Hirth, 1992). This 372 amino acid, 7 transmembrane GPCR (Kieffer et al., 1992; Knapp et al., 1994; Quock et al., 1999; Simonin et al., 1994) has high binding affinity for β-endorphin and leu-enkephalin (Evans et al., 1992; Kieffer et al., 1992). Brain regions in rats that exhibited high Oprd1 mRNA expression included the frontal cortex, hippocampus, NAc and amygdalar complex (Fig. 2), regions of interest for depression and anxiety, (Mansour et al., 1987).
Stress-induced modulation of pain: Role of the endogenous opioid system
2018, Progress in Brain ResearchBioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors
2015, Vitamins and HormonesCitation Excerpt :The ultimate discovery and isolation of the cDNA for the mouse delta-opioid receptor (mDOR1) from the labs of Evans in the United States and Kieffer in France in 1992 (Evans, Keith, Morrison, Magendzo, & Edwards, 1992; Kieffer, Befort, Gaveriaux-Ruff, & Hirth, 1992) for the first time linked an opioid receptor sequence to a pharmacologically defined opioid receptor. Once the mDOR cDNA sequence was known, homology cloning led to the identification of receptor sequences for numerous rodent, monkey, and the human opioid receptors, hMOR (Wang, Johnson, Persico, et al., 1994), hDOR (Knapp et al., 1994; Simonin et al., 1994), and hKOR (Mansson, Bare, & Yang, 1994; Simonin et al., 1995; Zhu et al., 1995). At the same time, cloning studies revealed another “opioid receptor-like” (ORL) sequence from numerous labs that was similar to an opioid receptor but did not look like one from pharmacological studies (Bunzow et al., 1994; Chen et al., 1994; Fukuda et al., 1994; Lachowicz, Shen, Monsma, & Sibley, 1995; Mollereau et al., 1994; Wang, Johnson, Imai, et al., 1994; Wick et al., 1994).
A comprehensive study on the putative δ-opioid receptor (sub)types using the highly selective δ-antagonist, Tyr-Tic-(2S,3R)-β-MePhe-Phe- OH
2011, Neurochemistry InternationalCitation Excerpt :However, the pharmacologically defined subtypes have not been identified at a molecular level to date (Allouche et al., 2000; Zaki et al., 1996). Only one δ-opioid receptor gene (DOR-1) has been cloned from the amphibian Rana pipiens (Stevens et al., 2007), mouse (Zhu et al., 1999), rat (Fukuda et al., 1993) and human (Knapp et al., 1994) brain so far. It has been shown that the DOR-1 gene encodes both δ1 and δ2 subtypes (Zhu et al., 1999).
Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies
2011, Bioorganic and Medicinal ChemistryCitation Excerpt :Three types of opioid receptors (μ, δ, κ) are now well established not only by pharmacological studies but also by molecular biological characterizations.1–4