Effect of centrally administered corticotropin releasing factor (CRF) on multiple feeding paradigms

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Abstract

Recently, a 41-residue corticotropin-releasing factor (CRF) has been characterized from the hypothalamus. In the present study, it was found that this stress-related peptide suppressed feeding induced by a variety of substances including muscimol, norepinephrine, dynorphin and insulin. These data suggest that the corticotropin-releasing factor may represent an important agent in stress-induced anorexia.

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