General paperBradykinin modulation of α2-Adrenoceptors in the nucleus tractus solitarii of the rat. An in vitro autoradiographical study
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Cited by (12)
The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit
2015, Respiratory Physiology and NeurobiologyCitation Excerpt :The results support our hypothesis that lisinopril could potentiate the cough reflex at the central level through an accumulation of protussive mediators such as bradykinin and substance P. All components necessary for the formation and metabolism of bradykinin and related kinins have been described in the brain, including the NTS (Bhoola et al., 1992; Diz, 1985). In more detail, high-affinity binding sites for bradykinin were found in the NTS (Fior and Fuxe, 1995; Privitera et al., 1992). The biological effects of bradykinin are mediated by its interactions with two distinct bradykinin receptor subtypes, the bradykinin B1 and B2 receptors.
Alpha2-adrenoceptor and adenosine A1 receptor within the nucleus tractus solitarii in hypertension development
2015, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :This neuromodulatory process is just a small piece of the complex puzzle of CNS organization that maintains body homeostasis. This fine-tuning modulation has been extensively studied in several systems (Zoli et al., 1993; Agnati et al., 2005; Abbracchio et al., 2009) particularly within the NTS (Yang et al., 1994; Fior and Fuxe, 1995; Xoriuchi et al., 1999; Diaz-Cabiale et al., 2000). Several studies focus on the interaction between alpha2-adrenoceptor and several other receptors, such as the angiotensin-II receptor (Fior et al., 1994, 1995; Jackson et al., 2005), endocannabinoid receptors (Pertwee, 2005), Adenosine receptors (Carrettiero et al., 2008, 2009), bradykinin receptors (Fior and Fuxe, 1995) and neuropeptide Y receptors (Yang et al., 1994).
Alpha <inf>2</inf>-adrenergic receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats during development
2012, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :Another interesting point is that the fine-tuning modulation of NTS systems also depends on receptor–receptor interaction. It has been extensively studied for alpha2R specially interacting with Angiotensine-II (Fior et al., 1995; Jackson et al., 2005), endocannabinoids (Pertwee, 2005), Adenosine (Carrettiero et al., 2008, 2009) and Bradykinin (Fior and Fuxe, 1995). It has also been describe that NTS astrocytes expressing alpha2R play a special role in modulating the excitability of NTS neurons (Bhuiyan et al., 2009; Yao, 2009).
Adenosine modulates alpha2-adrenergic receptors through a phospholipase C pathway in brainstem cell culture of rats
2009, Autonomic Neuroscience: Basic and ClinicalOpposite to α<inf>2</inf>-adrenergic agonists, an imidazoline I<inf>1</inf> selective compound does not influence reflex bradycardia in rabbits
2006, Autonomic Neuroscience: Basic and ClinicalPathophysiology of the kallikrein-kinin system in mammalian nervous tissue
1998, Pharmacology and Therapeutics