Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity
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Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser<sup>1412</sup> in the dentate gyrus of the rat brain
2018, Nitric Oxide - Biology and ChemistryNitric oxide in the nervous system. Biochemical, developmental, and neurobiological aspects
2014, Vitamins and HormonesPhosphorylation of neuronal nitric oxide synthase at Ser<sup>1412</sup> in the dentate gyrus of rat brain after transient forebrain ischemia
2013, Neurochemistry InternationalCitation Excerpt :These data suggest that NO from nNOS is supposed to produce detrimental effects in neurons after cerebral ischemia. nNOS is regulated by cyclic AMP-dependent protein kinase (PKA) (Bredt et al., 1992; Brune and Lapetina, 1991; Dinerman et al., 1994), protein kinase C (Bredt et al., 1992; Nakane et al., 1991) and calmodulin-dependent protein kinase (CaM-K) (Hayashi et al., 1999; Komeima et al., 2000; Song et al., 2004), but its physiological significance has not yet been fully explored. We previously demonstrated that nNOS is directly phosphorylated at Ser847 by CaM-KIIα, leading to a reduction in its activity in vitro and in situ (Hayashi et al., 1999; Komeima et al., 2000).
Regulation of Nitric Oxide Synthase by Calmodulin
2012, Calmodulin and Signal TransductionPartial neuroprotection by 17-β-estradiol in neonatal gamma-irradiated rat cerebellum
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