Oral Surgery, Oral Medicine, Oral Pathology
Nitrendipine-induced gingival hyperplasia: First case report
References (43)
- et al.
Gingival overgrowth induced by diltiazem
Oral Surg Oral Med Oral Pathol
(1988) - et al.
Gingival hyperplasia associated with nifedipine therapy
Report of a case
Oral Surg Oral Med Oral Pathol
(1984) - et al.
Fibrous hyperplasia of the gingiva: a side effect of cyclosporin A therapy
Oral Surg Oral Med Oral Pathol
(1983) - et al.
Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine
J Am Dent Assoc
(1987) - et al.
Gingival hyperplasia by nifedipine, an arterial vasodilating drug
Oral Surg Oral Med Oral Pathol
(1985) Hyperplasia of the gingiva associated with Dilantin therapy
J Am Dent Assoc
(1941)- et al.
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study
Oral Surg Oral Med Oral Pathol
(1988) - et al.
Protection by phenytoin and calcium channel blocking agents against the toxicity of diisopropyl fluorophosphate
Toxicol Appl Pharmacol
(1986) - et al.
Histologic evidence for impaired growth control in diphenylhydantoin gingival overgrowth in man
Arch Oral Biol
(1978) Epilepsy and the manifestations of phenytoin therapy
Nifedipine-induced gingival hyperplasia: a histochemical and ultrastructural study
J Periodontol
Felodipine compared to nifedipine as “third-line drug” in resistant hypertension
Angiology
Felodipine in patients with chronic heart failure: discrepant haemodynamic and clinical effects
Br Heart J
Cardiovascular and neurohumoral postural responses and baroreceptor abnormalities during a course of adjunctive vasodilator therapy with felodipine for congestive heart failure
Circulation
Felodipine, blood pressure, and cardiovascular reflexes in hypertensive humans
Hypertension
Comparison of nitrendipine with propranolol and its use in combined cardiovascular therapy
Am J Cardiol
Calcium channel antagonists and left ventricular function: effects of nitrendipine in congestive heart failure
Am J Cardiol
Implications of recent clinical trials in systemic hypertension
Results of multicenter trial of nitrendipine, for mild to moderately severe systemic hypertension
Am J Cardiol
Effect of the calcium channel blocker nitrendipine on left ventricular mass in patients with hypertension
Clin Pharmacol Ther
Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension
Jpn Heart J
Cited by (54)
Cardiovascular drugs-induced oral toxicities: A murky area to be revisited and illuminated
2015, Pharmacological ResearchCitation Excerpt :Nifedipine is the most important one among CCBs that was reported to cause gingival enlargement [95–97]. Other CCBs which have been shown to cause gingival enlargement are amlodipine [98,99], verapamil [100], felodipine [101,102], nicardipine [103], and nitrendipine [104]. Cessation of CCBs and a timely shift to other class of antihypertensive agents might be needed to prevent the gingival deterioration.
Gingival enlargement
2011, Journal of the American Dental AssociationCitation Excerpt :“Drug-influenced gingival enlargement” and “drug-induced gingival overgrowth” are the preferred terms for what previously was referred to as “gingival hyperplasia,” “gingival hypertrophy,” “gingival fibromatosis” and “elephantiasis gingivae.” The medications commonly associated with drug-influenced gingival enlargement include antihypertensive agents such as the calcium channel blockers (including nifedipine, diltiazem and verapamil, as well as antiseizure medications such as phenytoin, sodium valproate, valproic acid, phenobarbital and primidone.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 Immunosuppressants such as cyclosporin A also are implicated in gingival enlargement.
Connective Tissue Lesions
2011, Oral Pathology: Clinical Pathologic Correlations, Sixth EditionThe efficacy of azithromycin on cyclosporine-induced gingival enlargement: Systematic review and meta-analysis
2020, Journal of Oral Biology and Craniofacial ResearchCitation Excerpt :Several studies revealed the presence of some temporary improvement of the gingival enlargement and periodontal condition with surgical and non-surgical periodontal therapy.6–9 The enlarged gingiva (pseudo pocket) due to the drug facilitates the retention of bacterial plaque and predispose the person to dental caries, and periodontal disease.10,11 Azithromycin has been reported as manner an inhibitory effect on CsA-induced GO in human.12
Calcium channel blockers induced gingival overgrowth: A comprehensive review from a dental perspective
2022, Journal of International Society of Preventive and Community DentistryRole of histopathology in the management of the gingival enlargement in a patient on antihypertensive therapy based on calcium channel blockers: a case report
2022, Romanian Journal of Morphology and Embryology
- a
Associate Professor, Department of Oral Diagnostic Sciences, UTHSCH, Dental Branch.
- b
Clinical Instructor, Department of Oral Pathology, Georgetown University.
- c
Professor and Chairman, Department of Oral Pathology, Georgetown University.
- d
Professor and Chairman, Department of Oral Diagnosis, Georgetown University.