Effects of chronic administration of eldoisin or physalaemin on the rat salivary glands

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Abstract

The effects on the main salivary glands of the chronic administration of the naturally occurring peptides eledoisin (ELS) and physalaemin (PHYS) to rats were studied. Our experiments showed that: (1) chronic administration of PHYS, but not of ELS, produced enlargement of the main salivary glands; (2) chronic treatment with ELS did not modify, whilst chronic treatment with PHYS reduced, glandular sensitivity to single injections of ELS; (3) amylase activity of saliva from chronically ELS-treated rats exceeded amylase activity of saliva obtained from controls or chronically PHYS-treated rats, regardless of the inducer employed; (4) in our experimental conditions not only was PHYS a stronger agonist than ELS on a molar basis, but it also produced a saliva chemically different from the one evoked by ELS.

The possible role of these modifications in determining the therapeutic effect of PHYS and ELS was discussed.

References (15)

  • LowryO.H. et al.

    J. Biol. Chem.

    (1951)
  • SinghM. et al.

    Gastroenterology

    (1972)
  • BertacciniG. et al.

    Br. J. Pharmacol.

    (1965)
  • BertacciniG. et al.

    J. Physiol.

    (1965)
  • BertacciniG. et al.

    J. Pharm. Pharmacol.

    (1966)
  • BertacciniG. et al.

    J. Physiol.

    (1967)
  • BiettiG.B. et al.

    Bericht d. Opthalm. Ges.

    (1974)
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