Elsevier

Physiology & Behavior

Volume 19, Issue 4, October 1977, Pages 503-511
Physiology & Behavior

Effects of lesions in central thermosensitive areas on thermoregulatory responses in rat

https://doi.org/10.1016/0031-9384(77)90226-8Get rights and content

Abstract

Behavioral and autonomic responses elicited by ambient heat were tested before and after lesioning five thermosensitive areas previously localized in the rat brain. Lesions in the PO/AH area, where local warming elicits prone body extension, markedly reduced or abolished extension but had no effect on locomotion, grooming, or tail vasodilation. Lesions in the posterior hypothalamus, where local warming induces grooming, and lesions in the septum, medial midbrain, and dorsomedial medulla, where local warming evokes locomotion, had no significant effects on thermoregulatory responses except for reduced body extension following midbrain lesions, which may have interrupted the efferent path from PO/AH thermosensors. It was concluded that extension is predominantly dependent on PO/AH thermosensors and/or integrative interneurons, while locomotion, grooming, and vasodilation are controlled by input from peripheral and central sensors. The present and earlier data from the rat are less consistent with a relatively localized general integrating mechanism producing a unitary output signal to thermoregulatory effectors than with a spatially distributed network of specific paths from sensors to separate response mechanisms, where summation of inputs may occur.

References (37)

  • J.M. Lipton

    Effects of preoptic lesions on heat-escape responding and colonic temperature in the rat

    Physiol. Behav.

    (1968)
  • R.W. Swift et al.

    The heat production of the fasting rat in relation to the environmental temperature

    J. Nutr.

    (1939)
  • E.R. Adair

    Hypothalamic control of thermoregulatory behavior

  • L.L. Bernardis et al.

    The response of male and female rats with hypothalamic lesions to low and high environmental temperatures

    Experientia

    (1963)
  • J. Bligh

    Temperature Regulation in Mammals and Other Vertebrates

    (1973)
  • M. Cabanac

    Temperature regulation

    Ann. Rev. Physiol.

    (1974)
  • H.J. Carlisle

    Effect of preoptic and anterior hypothalamic lesions on behavioral thermoregulation in the cold

    J. comp. physiol. Psychol.

    (1969)
  • H.J. Carlisle et al.

    The effects of heating and cooling the spinal cord and hypothalamus on thermoregulatory behavior in the pig

    J. Physiol., Lond.

    (1973)
  • L.C.A. Conrad et al.

    Efferents from medial basal forebrain and hypothalamus in the rat. I. An autoradiographic study of the medial preoptic area

    J. comp. Neurol.

    (1976)
  • L.C.A. Conrad et al.

    Efferents from medial basal forebrain and hypothalamus in the rat. II. An autoradiographic study of the anterior hypothalamus

    J. comp. Neurol.

    (1976)
  • J. DeGroot

    The rat forebrain in stereotaxic coordinates

    Verh K. ned Akad. Wet.

    (1959)
  • C.A. Fuller et al.

    Shivering and nonshivering thermogenic responses of cold-exposed rats to hypothalamic warming

    Am. J. Physiol.

    (1975)
  • J.E. Gamble et al.

    Pulmonary edema and hemorrhage from preoptic lesions in rats

    Am. J. Physiol.

    (1953)
  • P.W. Han et al.

    Deficits of temperature regulation in rats with hypothalamic lesions

    Am. J. Physiol.

    (1961)
  • F.R. Hainsworth

    Saliva spreading, activity, and body temperature regulation in the rat

    Am. J. Physiol.

    (1967)
  • F.R. Hainsworth et al.

    Salivary cooling by rats in the heat

  • F.R. Hainsworth et al.

    Evaporative cooling in the rat: Differences between salivary glands as thermoregulatory effectors

    Can. J. Physiol. Pharmac.

    (1971)
  • H.T. Hammel

    Regulation of internal body temperature

    Ann. Rev. Physiol.

    (1968)
  • Cited by (0)

    This research was supported by Grant MH 06901 from the National Institute of Mental Health to W. W. Roberts. Grateful acknowledgement is made to Eunice K. Roberts for assistance.

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