Brief communicationComparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation
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Changes in D1 but not D2 dopamine or mu-opioid receptor expression in limbic and motor structures after lateral hypothalamus electrical self-stimulation: A quantitative autoradiographic study
2016, Neurobiology of Learning and MemoryCitation Excerpt :Some authors have examined the expression of D1 and D2 dopaminergic receptors in operant behaviors for feeding (Haberny & Carr, 2005; Narayanan, Land, Solder, Deisseroth, & DiLeone, 2012) and in the selection of instrumental responses related to reward (Koch et al., 2000); the expression of both DA and opioid receptors have also been examined in the self-administration of morphine and other drugs (Biscaia et al., 2008; Higuera-Matas et al., 2010; Le Marec, Marie-Claire, Noble, & Marie, 2011; Sanchez-Cardoso et al., 2007, 2009). There have also been mapping studies of brain areas in which metabolic activity was modified in response to unilateral rewarding self-stimulation of the MFB and dopaminergic antagonist administration (Gallistel, Gomita, Yadin, & Campbell, 1985), and which also showed the involvement of endogenous opioid activity in different rat strains (Gross-Isseroff, Cohen, & Shavit, 1992). With this background, the objective of the present study was to use quantitative autoradiography to examine the importance of the opioid (centering on mu receptors) and dopaminergic (investigating D1 and D2 receptor expression) systems in LH-induced self-stimulation behavior, in which both are reportedly involved.
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