Relationship of lethal toxic dose to body weight of the mouse
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Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists
2020, NeuroToxicologyCitation Excerpt :While all three GABAAR antagonists induce seizure-like phenotypes in 5 dpf zebrafish, TETS triggered both seizure behavior and electrographic activity at significantly lower waterborne concentrations than either PTZ or PTX (Figs. 6 and 8). Absent tissue levels of these anticonvulsant chemicals in larval zebrafish, we cannot make any definitive statements regarding relative potencies, but these findings are consistent with observations of rodent models, in which TETS is 30- to 100-fold more potent as a convulsant than PTX following systemic administration (Duka et al., 1979; Lamanna and Hart, 1968; Shandra et al., 1996; Vogel, 2008; Zolkowska et al., 2012). The basis for the high in vivo seizurogenic potency of TETS is not understood.
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2016, Behavioural ProcessesCitation Excerpt :Size. We may expect the larger species to be less neophobic towards the food than smaller ones, because the larger body size would contribute to easier physiological overcoming the adverse effects of noxious food (Lamanna and Hart, 1968; Anderson and Weber, 1975; Smith and Phillips, 2006). Larger passerine species also attack aposematic prey more frequently than smaller ones (Exnerová et al., 2003).
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