A teratogenic study of chlorpromazine, orphenadrine, perphenazine, and LSD-25 in rats

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Abstract

Pregnant rats were treated po with either perphenazine, chlorpromazine, orphenadrine or LSD-25 on days 6 through 15 after mating. On day 21, the pups were removed and examined for gross, visceral, and skeletal defects. The dams were examined for nidations, resorptions and reproductive performance. In all, 265 dams and 3454 offspring were evaluated. The results indicate that pregnant rats treated with near-lethal doses of perphenazine or chlorpromazine have more resorptions than controls. At one or more doses of all drugs, average offspring weights were less than control values. Visceral examination of the pups revealed that 7 dams from the 2 highest orphenadrine groups had abnormal offspring. In these groups, 8 of 157 pups had enlarged, darkened bladders. One abnormally developed pup was produced in the low-dose chlorpromazine group. All other rats treated with perphenazine, chlorpromazine or LSD-25 had normally developed offspring.

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