Distribution, excretion, and binding of radioactivity in the rat after intraperitoneal administration of the lung-toxic furan, [14C]4-ipomeanol

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Abstract

4-Ipomeanol [1-(3-furyl)-4-hydroxypentanone] is a poisonous metabolite produced in the mold-damaged sweet potato (Ipomoea batatas). In experimental animals the compound characteristically exhibits lung toxicity, producing prominent pulmonary edema and congestion. The distribution and excretion of radioactivity in rats after administration of [14C]4-ipomeanol has been studied. The toxin was given ip at doses of 2, 10, and 30 mg/kg. Approximately half of the administered radioactivity appeared in the urine within 2 hr, with only traces occurring in the feces and expired air. The greatest tissue concentration of radioactivity occurred in the lungs. Other organs showing significant concentrations were liver, kidney, and gastrointestinal tract. The maximal accumulation of activity occurred in the tissues within 0.5–1 h. The values declined over the next 1–2 hr, then reached a plateau representing residual activity. This residual activity is particularly high in lung, liver, and kidney, and represents the toxin or its metabolite(s) which has become tightly bound to tissue macromolecules. Binding occurs maximally in lung, and therefore may indicate that the binding phenomenon is involved in the toxic mechanism of 4-ipomeanol.

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Presented in part at the 13th Annual Meeting, Society of Toxicology, Washington, D.C. March 10–14, 1974.

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Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee.

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