The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
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Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains
2018, ToxicologyCitation Excerpt :Most of each parent compound (TCE and PCE) remained unmetabolized until excretion, the fraction of the total administered dose ranged from 61.7% to 84.3% for TCE, and from 90.3% to 93.5% for PCE. The unmetabolized fractions of TCE and PCE are likely cleared via exhalation, as shown in mice orally dosed with 500 mg/kg 14C-labelled PCE where exhalation fraction of PCE was 82.6% (Schumann et al., 1980). Excreted TCA accounted for 3.5%–7.1% of the total dose for TCE, and 6.4–9.4% for PCE.
Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
2011, Toxicology and Applied PharmacologyGlutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney
1998, Chemico-Biological InteractionsIn vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans
1996, Toxicology and Applied PharmacologyThe role of cytochrome P450 2E1 in the species-dependent biotransformation of 1,2-dichloro-1,1,2-trifluoroethane in rats and mice
1995, Toxicology and Applied Pharmacology
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