Effect of zinc pretreatment on mercuric chloride-induced lipid peroxidation in the rat kidney

https://doi.org/10.1016/0041-008X(84)90091-7Get rights and content

Abstract

The effect of zinc on mercuric chloride-induced lipid peroxidation in the rat kidney was investigated. The rats received zinc acetate (2.0 mmol/kg, po) for 2 days before being given mercuric chloride (15 μmol/kg, sc) and were killed 6, 12, and 24 hr after the last injection. Lipid peroxidation occurred in the rat kidney 12 hr after mercury administration, and this mercury-induced lipid peroxidation was significantly reduced by zinc pretreatment. A decrease in vitamin C and E contents in the kidney was observed 12 hr after the administration of mercury, and this decrease was prevented by zinc pretreatment. In the kidney of rats pretreated with zinc, the activities of the protective enzymes, glutathione peroxidase and glucose-6-phosphate dehydrogenase, were increased after mercury injection. Non-protein sulfhydryl content (mostly glutathione) also rose markedly. The results indicate that zinc not only induces metallothionein, but also increases protective enzyme activities and glutathione content, which would tend to inhibit lipid peroxidation and suppress mercury toxicity.

References (29)

  • M. Chvapil

    Effect of zinc on cell and biomembranes

    Med. Clin. N. Amer.

    (1976)
  • G.F. Combs et al.

    Mechanisms of action of selenium and vitamin E in protection of biological membranes

  • A. Emmerie

    Colorimetric determination of tocopherol (vitamin E) IV. Determination of tocopherol in oils after saponification

    Rev. Trav. Chim.

    (1940)
  • L. Friberg et al.

    Introduction

  • Cited by (83)

    • Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12 cells

      2021, Ecotoxicology and Environmental Safety
      Citation Excerpt :

      Moreover, Zn also persuades metallothionein synthesis. Moreover, antioxidant enzymes (such as GPx and glucose-6-phosphate dehydrogenase) restoration, increased amounts of vitamin C, vitamin E and GSH were considered as Zn induced protection mechanisms (Fukino et al., 1984). Numerous researchers confirmed about Zn-protection against oxidative stress in several diseases (Marreiro et al., 2017).

    • Mechanisms Involved in the Renal Handling and Toxicity of Mercury

      2018, Comprehensive Toxicology: Third Edition
    • Mechanisms of Toxicant-Induced Acute Kidney Injury

      2018, Comprehensive Toxicology: Third Edition
    • Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride

      2017, Animal Nutrition
      Citation Excerpt :

      In this study, olive flounder fed diets containing Hg showed lower vitamin E levels in liver, kidney and muscle tissues than fish fed diets without Hg. Fukino et al. (1984) reported inorganic Hg has been shown to alter the levels of nutrients such as vitamins C and E in the tissues because the vitamin C and E interacts with Hg. Interaction of vitamin E and Hg showed it alleviates MeHgCl and HgCl2 toxicity and neuronal degeneration which ultimately prevents lipid peroxidation due to Hg toxicity (Kasuya, 1975).

    • Dietary vitamin C reduced mercury contents in the tissues of juvenile olive flounder (Paralichthys olivaceus) exposed with and without mercury

      2016, Environmental Toxicology and Pharmacology
      Citation Excerpt :

      In case of kidney tissue, we observed that dietary groups between Hg20C0 and Hg20C100 had no further increment of AA contents; probably Hg reduces AA levels from kidney tissue of fish (Fig. 1.) which is consistent with Fukino et al. (1984). Yamamoto and Inoue (1985) reported that dietary Hg contamination increases vitamin C requirements of fish.

    View all citing articles on Scopus
    View full text