The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat
References (38)
- et al.
A spectrophotometric method of measuring the breakdown of hydrogen peroxide by catalase
J. Biol. Chem
(1952) - et al.
Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation
Biochem. Pharmacol
(1975) - et al.
Fatty acid oxidation by human liver peroxisomes
Biochem. Biophys. Res. Commun
(1979) - et al.
Genetic and biochemical studies on perchloroethylene “in vitro” and “in vivo”
Mutat. Res
(1983) - et al.
Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man
Food Cosmet. Toxicol
(1981) The metabolism of 36Cl-labeled trichloroethylene and tetrachloroethylene in the rat
Biochem. Pharmacol
(1963)- et al.
Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: Possible relevance to species differences in hepatocarcinogenicity
Toxicol. Appl. Pharmacol
(1985) - et al.
Chlorinated hydrocarbon induced peroxisome enzyme activity in relation to species and organ carcinogenicity
Toxicol. Appl. Pharmacol
(1987) - et al.
Species differences in response to trichloroethylene. II. Biotransformation in rats and mice
Toxicol. Appl. Pharmacol
(1985) - et al.
Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1-6N-etheno-adenosine
Toxicology
(1977)
Protein measurement with the Folin phenol reagent
J. Biol. Chem
Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice
Toxicol. Appl. Pharmacol
Biological actions and interactions of tetrachloroethylene
Mutat. Res
Effects of vinylidene chloride on DNA synthesis and DNA repair in the rat and mouse: A comparative study with dimethylnitrosamine
Toxicol. Appl. Pharmacol
The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
Toxicol. Appl. Pharmacol
Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadiene and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450 linked microsomal mono-oxygenases
Arch. Toxicol
Distribution of peroxisomes (microbodies in the nephron of the rat. A cytochemical study)
J. Cell Biol
Absorption elimination and metabolism of tetrachloroethylene
Naunyn-Schmiedeberg's Arch. Pharmacol. (Suppl.)
Novel chambers for long term inhalation studies
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Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice
2018, Toxicology and Applied PharmacologyCitation Excerpt :In vivo data for B6C3F1 and SW strains were reviewed thoroughly and used in the previous perc PBPK model (Chiu and Ginsberg, 2011). Studies in B6C3F1 mice included inhalation, closed chamber and oil gavage administration at a range of exposure levels, and reported perc and its oxidative metabolite, TCA, in blood (Gargas, 1988; Odum et al., 1988; Gearhart et al., 1993; Reitz et al., 1996). Only data using aqueous gavage of perc was available for the SW strain, reporting concentrations of perc in blood, liver and kidney, and its oxidative metabolite, TCA, in blood and liver (Philip et al., 2007).
Trichloroethylene-induced formic aciduria: Effect of dose, sex and strain of rat
2013, ToxicologyCitation Excerpt :So at this stage we cannot rule out that a strain difference in the production of TCE-OH and or TCA could explain the strain difference in formic aciduria. Interestingly, PCE which like TCE undergoes metabolism to generate TCA (Odum et al., 1988) showed little evidence of formic aciduria after 3 daily doses 16 mg/kg (Fig. 5). Other chlorinated solvents at higher doses also caused formic aciduria, namely carbon tetrachloride and chloroform (Fig. 5) and bromdichloromethane (Lock et al., 2004).
Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
2011, Toxicology and Applied PharmacologyA review of perchloroethylene and rat mononuclear cell leukemia
2006, Regulatory Toxicology and PharmacologyEffects of superoxide dismutase and polyclonal tumor necrosis factor-alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages
2004, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology