Comparative pharmacokinetics of 67Ga and 59Fe in humans

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Abstract

The comparative pharmacokinetics of 67Ga-citrate, 59Fe-citrate and 67Ga-transferrin was undertaken in three healthy male adults, and was found to differ significantly. Whereas the disappearance of 67Ga-citrate and 67Ga-transferrin from the plasma was best described by a three-exponential equation, that of 59Fe-citrate up to 12 h after injection, best fit a two-exponential function. Statistically significant differences between 59Fe-citrate and 67Ga-citrate were observed for the overall elimination rate constant, half-life, volume of distribution and plasma clearance. A marked difference in red blood cell uptake of these two nuclides was also observed. The in vivo organ distribution of 59Fe was found to be very different from that of 67Ga in the regions of interest studied. There were no significant differences in the in vivo organ uptake of 67Ga-citrate, and 67Ga-transferrin.

Thus, the disposition of 67Ga and 59Fe in human subjects was not similar despite their common association with transferrin. Other factors must be involved in the uptake of these radionuclides by the various body tissues.

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