Hepatic cytochrome P-4503A (CYP3A) activity in the elderly
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2018, Advanced Drug Delivery ReviewsCitation Excerpt :Blanco et al. [32] investigated age related changes in microsomal CYP1A2 (ethoxyresorufin), CYP2E1 (ethoxycoumarin), CYP3A4/5 (midazolam) and CYP2C8 (paclitaxel 17α position) and found no age related change in activity between subjects >60 years compared to those >10 to 59 years. Previously Hunt et al. had also demonstrated no change in CYP3A activity in vitro with age (range 27 to 83 years) [33] and also in vivo using the erythromycin breath test between an older (70 to 88 years) compared to a younger age group (20 to 60 years) [34]. In another study the same authors showed no change in CYP2E1 activity over the range of 30 to 75 years [35].