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Cited by (68)
Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study
2017, Seminars in Arthritis and RheumatismCitation Excerpt :Gastrointestinal toxicities are most frequent, with a prevalence of 20–65%, and are usually characterized by mild or moderate severity (e.g., nausea, vomiting, diarrhea, and abdominal pain) [13,16–19]. Liver toxicity is a common concern and up to 20% of LDM users are estimated to have at least one episode of elevated serum transaminases, and 3.7% discontinue LDM due to liver toxicity [13,20–26]. Interstitial pneumonitis represents the most serious respiratory toxicity for LDM, presenting as an acute hypersensitivity reaction with cough, fever, and subacute dyspnea, with mortality rates estimated up to 17% [27,28].
Vascular disorders
2012, MacSween's Pathology of the LiverVascular Disorders
2011, MacSween's Pathology of the Liver: Expert Consult: Online and PrintObesity and psoriasis: From the Medical Board of the National Psoriasis Foundation
2010, Journal of the American Academy of DermatologyIs methotrexate hepatotoxicity associated with cumulative dose? A systematic review and meta-analysis
2021, Australasian Journal of DermatologyAssessment of hepatic fibrosis by transient elastography in rheumatoid arthritis patients receiving methotrexate
2020, Scientific Journal of Kurdistan University of Medical Sciences
- 1
From the Section of Rheumatology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV.
- 2
From the Section of Comprehensive Medicine, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV.
- 3
From the Section of Gastroenterology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV.
- 4
From the Department of Pathology, West Virginia University School of Medicine, Morgantown, WV.