Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium
References (54)
- et al.
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides
Prostaglandins
(1976) - et al.
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation
Prostaglandins
(1976) - et al.
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation
Prostaglandins
(1976) - et al.
Human arterial and venous tissues generate prostacyclin (Prostaglandin X), a potent inhibitor of platelet aggregation
Lancet
(1977) - et al.
The chemical characterization of prostaglandin X (prostacyclin)
Prostaglandins
(1976) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
On the specificity of oxygenation of unsaturated fatty acids catalysed by soyabean lipoxygenase
J. Biol. Chem.
(1967) - et al.
Response of platelets to tissue injury
Biochem. Pharmacol. Suppl.
(1968) - et al.
An endoperoxide aggregator (LASS) formed in platelets in response to thrombotic stimuli
Prostaglandins
(1974) - et al.
The effect of inhibition of prostaglandin synthesis on microvascular haemostasis and macromolecular leakage
Thromb. Res.
(1976)
The effect of aspirin on platelet function in humans
Thromb. Res.
The fine structure of experimental thrombi
The structure of haemostatic plugs and experimental thrombi in small arteries
Br. J. exp. Pathol.
Role of platelets in thrombosis
Thromb. Diath. haemorrh. Suppl.
Experimental platelet thrombus
Thromb. Diath. haemorrh. Suppl.
Vascular endothelial damage and thrombosis
Adv. Cardiol.
Vascular endothelium and thrombogenesis
The subendothelium and thrombogenesis
Bull. N.Y. Acad. Med.
The ultrastructure of initial stages of platelet aggregation and adhesion to damaged vessel walls in vivo
Br. J. exp. Pathol.
The role of the endothelium in the initial phases of thrombosis
Am. J. Pathol.
Platelets in hemostasis and thrombosis
Platelet interaction with vascular structures
Thromb. Diath. haemorrh. Suppl.
Platelet aggregation at site of minimal endothelial injury
The ultrastructure of early platelet aggregation in vivo
Am. J. Pathol.
Platelet adhesion in the rabbit abdominal aorta following the removal of the endothelium: a scanning and transmission electron microscopical study
The vascular wall in the pathogenesis of thrombosis
Thromb. Diath. haemorrh. Suppl.
The adhesiveness of native platelets and its prevention
J. Clin. Pathol.
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2016, Pharmacological ResearchCitation Excerpt :Especially relevant for the topic of the present review is that this paper also put forward the notion of a paracrine control of the tone of the vessel wall: “The fact that PGX is locally generated in the arterial wall and can relax smooth muscle also suggests that it plays a part in the local control of vascular tone”. Shortly after this publication, the differential formation of prostacyclin by the different layers of the vessel wall was reported by this group [26] showing this is highest in the endothelial layer, thus providing the endothelium for the first time a leading role in the local control of vascular tone (Fig. 1). Still, and maybe confounded by the fact the media and adventitia also released some prostacyclin [26], the notion of an endothelially-centered control of vascular tone, could not be established.
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Present address: Dept. of Pharmacology, Universitaire Instelling Antwerpen, Universiteitsplein 1, 2610 Wilrijk, Belgium.