Nucleoside transport in normal and neoplastic cells
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2018, PET ClinicsCitation Excerpt :FLT enters tissue by Na+-dependent active transporters dominated by human equilibrative nucleoside transporter 1. The level of this transporter increases as proliferating cells enter the cell cycle; accordingly, the expression is upregulated in the setting of cancer45 and this might influence radiotracer uptake and signal in the in vivo setting.46 [ 18F]FLT is phosphorylated in the cells by thymidine kinase-1 resulting in intracellular trapping and accumulation of this tracer; but unlike thymidine, FLT is not incorporated into the DNA structure.
Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers
2013, Drug Metabolism and PharmacokineticsNovel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer
2012, European Journal of Medicinal ChemistryCitation Excerpt :Curtin NJ and colleagues [25] showed that pyrimido[5,4-d]pyrimidines act as anti-metabolites, although they were designed as anti-cancer agents, and they still represent a major class with wide therapeutic applications today. Salvage of extracellular purine or pyrimidine nucleosides or bases constitutes an intrinsic resistance mechanism to anti-metabolite inhibitors of de novo purine or pyrimidine biosynthesis [26,27]. The pyrimido–pyrimidine cardiovascular agent DP inhibits equilibrative nucleoside transporters [28–30].
Exogenous nucleosides modulate expression and activity of transcription factors in Caco-2 cells
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