Clinical Immunology and Immunopathology
Anti-basement membrane antibodies and antigen-antibody complexes in rabbits injected with mercuric chloride☆
References (39)
- et al.
Immunochemistry
(1965) - et al.
Clin. Immunol. Immunopathol.
(1972) - et al.
J. Immunol. Methods
(1976) - et al.
The Kidney
- et al.
Amer. J. Pathol.
(1968) - et al.
Amer. J. Pathol.
(1971) - et al.
Lancet
(1963) - et al.
Arch. Environ. Health
(1972) - et al.
Arch. Intern. Med.
J. Histochem. Cytochem.
J. Pathol. Bact.
J. Cell. Biol.
J. Clin. Invest.
J. Exp. Med.
J. Exp. Med.
Science
N. Engl. J. Med.
Cited by (65)
Mercury-induced inflammation and autoimmunity
2019, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Although renal damage following inorganic mercury exposure in humans was known by the 1950s [118], it was not until the early 1970s that studies described glomerulonephritis mediated by immune complex deposits in rat based experimental models [119]. These observations were followed by reports of anti-glomerular basement membrane (GBM) autoantibodies in rats [120] and rabbits [121], and ANA in rats [122]. In mice, HgCl2-induced ANA were found to include anti-nucleolar autoantibodies (ANoA) [123] subsequently identified as antibodies against fibrillarin, a 37-kDa protein component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [124,125].
Mechanisms Involved in the Renal Handling and Toxicity of Mercury
2018, Comprehensive Toxicology: Third EditionAn experimental assessment of toxic potential of nanoparticle preparation of heavy metals in streptozotocin induced diabetes
2013, Experimental and Toxicologic PathologyCitation Excerpt :MT can bind with most of the heavy metals with varying degree of binding affinity, but amongst the metals present in the formulation studied, mercury has the highest affinity for MT. The presence of mercury was confirmed in our study with autometallography. In rabbits, rats, and mice, multiple exposures to inorganic mercury can induce the production of antibodies against the glomerular basement membrane, deposition of immune complexes in the mesangium and glomerular basement membrane (Bigazzi, 1992; Hultman and Enestrom, 1992; Roman-Franco et al., 1978). Inorganic mercury also induces cellular necrosis characterized by macrophage infiltration and hence tubular fibrosis and tubulointerstitial injury in the proximal tubule, especially in the pars recta segment even at low doses.
Renal Handling and Toxicity of Mercury
2010, Comprehensive Toxicology, Second EditionMercury vapour (Hg<sup>0</sup>): Continuing toxicological uncertainties, and establishing a Canadian reference exposure level
2009, Regulatory Toxicology and PharmacologyDose and Hg species determine the T-helper cell activation in murine autoimmunity
2007, ToxicologyCitation Excerpt :Induction of autoimmunity by inorganic mercury (Hg2+) has been described in rats, mice and rabbits (Sapin et al., 1977; Roman-Franco et al., 1978; Hultman et al., 1996).
- ☆
The results of these studies were presented to the 6th Annual Meeting of the American Society of Nephrology, Washington, D.C., November 1976.
- 2
Present address: Department of Pathology and Legal Medicine, University of Puerto Rico, San Juan, Puerto Rico.
- 3
Present address: University Hospital, Cardoba, Argentina.
- 4
Present address: Clinica Medica Universita, Padova, Italy.